This consortium establishes a national academic infrastructure called NL-OPENSCREEN open to the Dutch life science community. Through NL-OPENSCREEN we will make small-molecule libraries and screening facilities available for high throughput and cell based testing against bio-molecular targets of scientific interest. Optimization programs will be provided, in which hit-structures are developed by chemical modification. This provides new and enabling research tools for fundamental biological and biomedical studies, as well as for further development into drug candidates.