NL-OPENSCREEN

Assay Development and Translation

NL-OPENSCREEN will assist users with the translation of bench-top assays into assay suitable for high-throughput or phenotypic screening.
Computational chemical biology and cheminformatics

Computational methods are routinely used in drug discovery and lead optimization projects. Within NL-OPENSCREEN ample expertise is available in the application of computational chemical biology and cheminformatics.
Ligand engagement / target binding kinetics

NL-OPENSCREEN has assembled ample expertise to add precise pharmacological texture to the screening results, by integrating ligand engagement/target binding kinetics into the various screening protocols.
Ultra-High Throughput Screening

State-of-the-art equipment at the Pivot Park Screening Centre is used to run screens in 384 or 1536-well format
Target/Focused Screening

NL-OPENSCREEN will assemble high-quality targeted/focused compound libraries aimed at specific target protein families that will provide higher success rates.
Phenotypic Screening

Screen the cellular phenotypes of compound libraries in multiple dimensions.
Activity-Based Proteome Profiling

Activity-based proteome profiling is an attractive and powerful chemical biological technique that accelerates most stages of the drug discovery process.
EU-Openscreen

NL-OPENSCREEN is an integral part of the pan-European EU-OPENSCREEN network.

NL-OPENSCREEN

This consortium establishes a national academic infrastructure called NL-OPENSCREEN open to the Dutch life science community. Through NL-OPENSCREEN we will make small-molecule libraries and screening facilities available for high throughput and cell based testing against bio-molecular targets of scientific interest. Optimization programs will be provided, in which hit-structures are developed by chemical modification. This provides new and enabling research tools for fundamental biological and biomedical studies, as well as for further development into drug candidates.

Assay Development and Translation

NL-OPENSCREEN will assist users with the translation of bench-top assays into assay suitable for high-throughput or phenotypic screening.

Ultra-High Throughput Screening

Pivot Park Screening Centre accelerates drug discovery by using their long expertise on (u)HTS and their state-of-the-art robotic equipment to run screens in 384 or 1536-well format on a high quality compound library.

Target/Focused Screening

NL-OPENSCREEN will assemble high-quality targeted/focused compound libraries aimed at specific target protein families that will provide higher success rates.

Phenotypic Screening: See your cells

Screen the cellular phenotypes of compound libraries in multiple dimensions.

Activity-Based Proteome Profiling

Activity-based proteome profiling (ABPP) is an attractive and powerful chemical biological technique that accelerates most stages of the drug discovery process.

EU-Openscreen

NL-OPENSCREEN is an integral part of the pan-European EU-OPENSCREEN network.

Computational chemical biology and cheminformatics

Computational methods are routinely used in drug discovery and lead optimization projects. Within NL-OPENSCREEN ample expertise is available in the application of computational chemical biology (‘big data approaches’) and cheminformatics.

Ligand engagement / target binding kinetics

NL-OPENSCREEN has assembled ample expertise to add precise pharmacological texture to the screening results, by integrating ligand engagement / target binding kinetics into the various screening protocols.